Significant uterine anomaly

1. Severe Asherman’s Syndrome

2. Unicornuate uterus

Absence of uterus (congenital, acquired)

1. MRKH/Mullerian agenesis

2. Prior hysterectomy

Medical contraindications for pregnancy:

1. Pulmonary hypertension

2. Turner’s Syndrome/Turner’s Mosaic with compromised cardiac function

3. Cardiac diagnosis that increases risk of comorbidity during pregnancy

4. Prior poor obstetric history

   1. Placenta accreta

   2. Uncontrolled diabetes mellitus

   3. Uncontrolled hypertension

5. Cancer diagnosis

Uterine factor

Recurrent implantation failure (definition variable) - failed transfer of three good quality embryos vs three euploid embryos

Prior IVF with embryos in storage with subsequent maternal death

Prior IVF with embryos in storage with subsequent maternal death

Recurrent pregnancy loss

Definition by ASRM: two or more failed clinical pregnancies

Advanced maternal age

Case by case consideration (likely age > 55 years)